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2 "Choon Taek Lee"
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Original Articles
Alteration of the E-Cadherin/β-Catenin Complex Is an Independent Poor Prognostic Factor in Lung Adenocarcinoma
Hyojin Kim, Seol Bong Yoo, Pingli Sun, Yan Jin, Sanghoon Jheon, Choon Taek Lee, Jin-Haeng Chung
Korean J Pathol. 2013;47(1):44-51.   Published online February 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.1.44
  • 9,809 View
  • 44 Download
  • 35 Crossref
AbstractAbstract PDF
Background

Epithelial-mesenchymal transition (EMT) is an important step in the invasion and progression of cancer and in the development of chemoresistance by cancer cells.

Methods

To address the clinical significance of the EMT pathway in lung adenocarcinoma and the association of the pathway with histological subtype, we examined 193 surgically resected lung adenocarcinoma samples for the expression of representative EMT-related proteins (E-cadherin, β-catenin, and vimentin) by immunohistochemistry. Histological subtypes were classified according to the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification. The results for EMT-related protein expression were analyzed for correlation with clinicopathological features and with survival.

Results

The loss of E-cadherin expression and aberrant β-catenin expression were significantly associated with larger tumor size, pleural invasion, lymphatic/vascular invasion, and advanced pathological stage (p<0.05). The alteration of the E-cadherin/β-catenin complex was least frequently observed in the lepidic-predominant group, but these associations were not statistically significant. In the multivariate analysis, altered E-cadherin/β-catenin complex expression was found to be an independent poor prognostic factor (p=0.017; hazard ratio, 1.926; 95% confidence interval, 1.119 to 3.314).

Conclusions

The alteration of the expression of the E-cadherin/β-catenin complex was associated with aggressive tumor behavior in lung adenocarcinoma.

Citations

Citations to this article as recorded by  
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    Eunhyang Park, Soo Young Park, Ping-Li Sun, Yan Jin, Ji Eun Kim, Sanghoon Jheon, Kwhanmien Kim, Choon Taek Lee, Hyojin Kim, Jin-Haeng Chung
    Oncotarget.2106; 7(27): 42502.     CrossRef
  • Epigenetic Alterations of DNA Methylation and miRNA Contribution to Lung Adenocarcinoma
    Wenhan Cai, Miao Jing, Jiaxin Wen, Hua Guo, Zhiqiang Xue
    Frontiers in Genetics.2022;[Epub]     CrossRef
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    Hyojin Kim, Jeong Mi Yang, Yan Jin, Sanghoon Jheon, Kwhanmien Kim, Choon Taek Lee, Jin-Haeng Chung, Jin Ho Paik
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    DAE HYUN SONG, GYUNG HYUCK KO, JEONG HEE LEE, JONG SIL LEE, GYEONG-WON LEE, HYEON CHEOL KIM, JUNG WOOK YANG, ROK WON HEO, GU SEOB ROH, SUN-YOUNG HAN, DONG CHUL KIM
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    Qiong Shi, Xu Song, Jun Wang, Jia Gu, Weijian Zhang, Jinxia Hu, Xiuping Zhou, Rutong Yu
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    Lanhai Lü, Xiqiang Liu, Cheng Wang, Fengchun Hu, Jianning Wang, Hongzhang Huang
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    A N Seo, J M Yang, H Kim, S Jheon, K Kim, C T Lee, Y Jin, S Yun, J-H Chung, J H Paik
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  • The Clinicopathological Significance of Epithelial Mesenchymal Transition Associated Protein Expression in Head and Neck Squamous Cell Carcinoma
    Kyu Ho Kim, Lucia Kim, Suk Jin Choi, Jee Young Han, Joon Mee Kim, Young Chae Chu, Young-Mo Kim, In Suh Park, Joo Han Lim
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    Xia Fang, Pan Gu, Caicun Zhou, Aibin Liang, Shenxiang Ren, Fang Liu, Yu Zeng, Yunjin Wu, Yinmin Zhao, Binbin Huang, Zongmei Zhang, Xianghua Yi
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    Guofeng Yu, Yingying Jing, Xingrui Kou, Fei Ye, Lu Gao, Qingmin Fan, Yang Yang, Qiudong Zhao, Rong Li, Mengchao Wu, Lixin Wei, Xin-Yuan Guan
    PLoS ONE.2013; 8(9): e73312.     CrossRef
  • A Comprehensive Comparative Analysis of the Histomorphological Features of ALK-Rearranged Lung Adenocarcinoma Based on Driver Oncogene Mutations: Frequent Expression of Epithelial-Mesenchymal Transition Markers than Other Genotype
    Hyojin Kim, Se Jin Jang, Doo Hyun Chung, Seol Bong Yoo, Pingli Sun, Yan Jin, Kyung Han Nam, Jin-Ho Paik, Jin-Haeng Chung, Alfredo Fusco
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  • Non-small cell lung cancer cells survived ionizing radiation treatment display cancer stem cell and epithelial-mesenchymal transition phenotypes
    Roberto Gomez-Casal, Chitralekha Bhattacharya, Nandita Ganesh, Lisa Bailey, Per Basse, Michael Gibson, Michael Epperly, Vera Levina
    Molecular Cancer.2013;[Epub]     CrossRef
Loss of PTEN Expression is an Independent Poor Prognostic Factor in Non-small Cell Lung Cancer.
Seol Bong Yoo, Xianhua Xu, Hyun Ju Lee, Sanghoon Jheon, Choon Taek Lee, Gheeyoung Choe, Jin Haeng Chung
Korean J Pathol. 2011;45(4):329-335.
DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.4.329
  • 4,232 View
  • 34 Download
  • 9 Crossref
AbstractAbstract PDF
BACKGROUND
Alterations in the phosphatase and tensin homolog (PTEN) are correlated with tumor progression. Downregulation of PTEN is related to drug resistance of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in non-small cell lung cancer (NSCLC). The aim of this study was to evaluate the prognostic significance of PTEN in patients with NSCLC and its correlation with EGFR.
METHODS
Two hundred eighty eight surgically resected NSCLC samples, including 168 adenocarcinomas (ADCs), 99 squamous cell carcinomas (SCCs) and 21 other NSCLCs were analyzed for the PTEN. The results were correlated with other clinicopathological variables including EGFR amplification and mutation.
RESULTS
Loss of PTEN was detected in 42.4% of NSCLCs, specifically 28.6% of ADCs, 66.7% of SCCs, and 38.1% of others. Loss of PTEN was significantly associated with SCC, smoking, male gender, and higher stage. In a multivariate analysis, loss of PTEN was significantly associated with short progression-free survival (p=0.037). No association between PTEN and EGFR was observed.
CONCLUSIONS
These results suggest that loss of PTEN results in shorter progression-free survival in patients with NSCLC, and loss of PTEN is more associated with SCC, smoking, male gender, and higher T stage by the 7th tumor, node and metastasis staging system but not EGFR status.

Citations

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J Pathol Transl Med : Journal of Pathology and Translational Medicine